Combate Global took place on Friday, May 14. 2021. with 5 fights at Univision Studios in Miami, Florida. The card was headlined by 130-pound catchweight matchup between Jesus Santos Aguilar and “Scorpio” Cristian Barraza.
Aguilar was at the time on a five fight winning streak, capped off by a win over TUF 24 contestant and Dana White Contender Series veteran Jaime Alvarez. The Chilean Barraza also had a five fight winning streak, but Aguilar was the biggest test of his career, this was also his debut in Combate Global. The co-main event brought together two atomweight fighters, Ana Palacious was looking for her fourth win in a row against Gloria Barrios.